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The renal clearance of hydrochlorothiazide in individuals with regular renal functionality is 285mL/min. Individuals having a creatinine clearance of 31-80mL/min have an average hydroxychlorothiazide renal clearance of 75mL/min, and patients having a creatinine clearance of ≤30mL/min have a median hydroxychlorothiazide renal clearance of 17mL/min
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